Hyocholic acid

Research use only, not for human use.

Hyocholic acid is a natural product for research related to life sciences. The catalog number is TN7024 and the CAS number is 547-75-1.

Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .

HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells.HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells.Western Blot Analysis Cell Line:NCI-H716 cells Concentration:50 μM Incubation Time:48 h Result:Inhibited the high expression of SHP (small heterodimer partner) induced by the FXR agonist.

Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs.Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models.Animal Model:BA depletion pigs Dosage:20 mg/kg Administration:Oral administration (p.o.) Result:Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.Animal Model:db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model Dosage:100 mg/kg/day Administration:Oral administration (p.o.) Result:Improved oral glucose tolerances shown by lower glucose levels.Increased circulating active GLP-1 levels and fasting insulin levels.

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Others

Other Targets

Others

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547-75-1

408.57

C24H40O5

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (152.97 mM; Ultrasonic (<60°C)

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(-20℃)

With Ice Pack

≥ 2 years